A method of treating acetaminophen overdose, comprising: using a stable aqueous pharmaceutical composition comprising 200 mg/ml acetylcysteine or pharmaceutically acceptable salts thereof, wherein the composition is free of chelating agents, wherein said composition is in a suitable form for intravenous injection, wherein the pH of the composition is from 6 to 7.5, and wherein said composition is sealed in an airtight container comprising a fill volume of said composition and a headspace volume occupied by a pharmaceutically inert gas; diluting the composition in an aqueous solution; and administering the diluted composition to a patient in need thereof. view more

The method of claim 1, wherein the aqueous solution comprises at least one of 5% dextrose, 0.45% sodium chloride, and water for injection.

The method of claim 1, wherein the diluted composition is administered as a loading dose of 150 mg/kg, followed by a second dose of 50 mg/kg, followed by a third dose of 100 mg/kg.

The method of claim 1, wherein the total dose of diluted composition administered is 300 mg/kg.

The method of claim 1, wherein the pH of the composition is from 6.0 to less than 7.0.

A method of treating acetaminophen overdose, comprising: using a stable aqueous pharmaceutical composition comprising from 200 mg/ml to 250 mg/ml acetylcysteine or pharmaceutically acceptable salts thereof, wherein the composition is free of chelating agents, wherein said composition is in a suitable form for intravenous injection, wherein the pH of the composition is from 6 to 7.5, and wherein said composition is sealed in an airtight container comprising a fill volume of said composition and a headspace volume occupied by a pharmaceutically inert gas; diluting the composition in an aqueous solution; and administering the diluted composition to a patient in need thereof. view more

The method of claim 6, wherein the aqueous solution comprises at least one of 5% dextrose, 0.45% sodium chloride, and water for injection.

The method of claim 6, wherein the diluted composition is administered as a loading dose of 150 mg/kg, followed by a second dose of 50 mg/kg, followed by a third dose of 100 mg/kg.

The method of claim 6, wherein the total dose of diluted composition administered is 300 ma/ka.

A method of treating acetaminophen overdose-induced liver damage, comprising: using a stable aqueous pharmaceutical composition comprising 200 mg/ml acetylcysteine or pharmaceutically acceptable salts thereof, wherein the composition is free of chelating agents, wherein said composition is in a suitable form for intravenous injection, wherein the pH of the composition is from 6 to 7.5, and wherein said composition is sealed in an airtight container comprising a fill volume of said composition and a headspace volume occupied by a pharmaceutically inert gas; diluting the composition in an aqueous solution; and administering the diluted composition to a patient in need thereof. view more

The method of claim 10, wherein the pH of the composition is from 6.0 to less than 7.0.

The method of claim 10, wherein the aqueous solution comprises at least one of 5% dextrose, 0.45% sodium chloride, and water for injection.

The method of claim 10, wherein the diluted composition is administered as a loading dose of 150 mg/kg, followed by a second dose of 50 mg/kg, followed by a third dose of 100 mg/kg.

The method of claim 10, wherein the total dose of diluted composition administered is 300 mg/kg.