The protein of claim 1, wherein the protein consists essentially of the extracellular region of the insoluble human TNF receptor and all the domains of the constant region of a human IgG<sub>1 </sub>immunoglobulin heavy chain other than the first he constant region. view more

A pharmaceutical composition comprising the protein of claim 11 and a pharmaceutically acceptable carrier material.

The protein of claim 30, wherein the protein consists essentially of the extracellular region of the human tumor necrosis factor (TNF) receptor amino acid sequence encoded by the cDNA insert, and all the domains of the constant region of a human IgG₁ immunoglobulin heavy chain other than the first domain of the constant region. view more

A pharmaceutical composition comprising the protein of claim 35 and a pharmaceutically acceptable carrier material.

The method of claim 1, wherein the IgG heavy chain is an IgG<sub>1 </sub>heavy chain.

The method of claim 7, wherein the human IgG immunoglobulin heavy chain is an IgG<sub>1 </sub>heavy chain.

The method of claim 8, wherein the host cell is a CHO cell.