Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection
DCFirst Claim
1. A method of improving the health of a subject to increase the plasma level of arginine in the subject to a level from a low or normal fasting level to a level which is up to three times an average overnight fasting level, comprising orally administering a substance selected from the group consisting of L-citrulline and the calcium salt of L-citrulline.
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Abstract
This invention is a novel method in orthomolecular health to sustain favorable amounts of L-arginine efficiently within the human body for preservation of good health and amelioration of various disease states. The method provides administration of sizable amounts of L-citrulline as precursor substance for bioconversion to L-arginine in order to maintain greater blood plasma concentrations of L-arginine as potential substrate for various metabolic functions. The method is useful to increase the availability of substrate for nitric oxide production by constitutive nitric oxide synthases. Embodiments include uses of exogenous L-citrulline for more vasoprotection in sickle cell disease and atherosclerosis, more stability in circulating platelets, more relaxative smooth muscle tone during pregnancy and in achalasia, greater defense against angiostenosis after angioplasty, greater defense against oxidative stress, enhanced cell stores of creatine, enhanced fertility in males with oligospermia, and greater defense against osteoporosis.
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30 Claims
- 1. A method of improving the health of a subject to increase the plasma level of arginine in the subject to a level from a low or normal fasting level to a level which is up to three times an average overnight fasting level, comprising orally administering a substance selected from the group consisting of L-citrulline and the calcium salt of L-citrulline.
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