Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection

This invention is a novel method in orthomolecular medicine to sustain favorable amounts of L-arginine efficiently within the human body for preservation of good health and amelioration of various disease states. The method provides administration of sizable amounts of L-citrulline as precursor substance for bioconversion to L-arginine in order to maintain greater blood plasma concentrations of L-arginine as potential substrate for various metabolic functions. The method is useful to increase the availability of substrate for nitric oxide production by constitutive nitric oxide synthases. Embodiments include uses of exogenous L-citrulline for more vasoprotection in sickle cell disease and atherosclerosis, more stability in circulating platelets, more relaxative smooth muscle tone during pregnancy and in achalasia, greater defense against restenosis after angioplasty, greater defense against oxidative stress, enhanced cell stores of creatine, and enhanced fertility in males with oligospermia.