Stable liquid paracetamol compositions, and method for preparing same
DC CAFC
First Claim
1. A stable, liquid formulation consisting essentially of acetaminophen dispersed in an aqueous medium containing a buffering agent and at least one member of the group consisting of a free radical scavenger and a radical antagonist.
2 Assignments
Litigations
0 Petitions
Reexamination
Accused Products
Abstract
Novel stable paracetamol compositions for use in therapeutic chemistry and specifically galenic pharmacy are disclosed. The compositions contain a solution of paracetamol in an aqueous solvent combined with a buffer having a pH of 4 to 8, and a free radical capturing agent. A water-insoluble inert gas is carefully bubbled through the aqueous solvent to remove oxygen from the medium. Said compositions may also be combined with a centrally or peripherally acting analgesic agent, and are provided as injectable compositions for relieving pain.
74 Citations
28 Claims
- 1. A stable, liquid formulation consisting essentially of acetaminophen dispersed in an aqueous medium containing a buffering agent and at least one member of the group consisting of a free radical scavenger and a radical antagonist.
Specification
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- Resources
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Current AssigneeSCR Pharmatop
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Original AssigneeSCR Pharmatop
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InventorsFredj, Daniele, Dietlin, Francois
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Primary Examiner(s)Kumar, Shailendra
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Application NumberUS09/051,246Time in Patent Office627 DaysField of Search564/4, 564/5, 564/6, 564/7, 564/2, 564/223, 514/617US Class Current564/4CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/165 having aromatic rings, e.g....A61K 31/167 having the nitrogen of a ca...A61K 31/485 Morphinan derivatives, e.g....A61K 47/02 Inorganic compoundsA61K 47/10 Alcohols; Phenols; Salts th...A61K 47/12 Carboxylic acids; Salts or ...A61K 47/20 containing sulfur, e.g. dim...A61K 47/22 Heterocyclic compounds, e.g...A61K 9/0019 Injectable compositions; In...A61P 25/04 Centrally acting analgesics...A61P 29/00 Non-central analgesic, anti...
