Insecticidal combination to control mammal fleas, in particular fleas on cats and dogs
DC CAFC
First Claim
Patent Images
1. A synergistic spot-on composition for the long lasting protection against fleas and ticks on mammals which comprises synergistic effective amounts of Fipronil synergistic amount of a compound which mimics juvenile hormones and at least one customary spot-on formulation adjuvant.
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Abstract
Process and composition, in particular for controlling fleas on small mammals, characterized in that the composition includes, on the one hand, at least one insecticide of 1-N-arylpyrazole type, in particular fipronil, and, on the other hand, at least one compound of IGR (insect growth regulator) type, in doses and proportions which are parasiticidally effective on fleas, in a fluid vehicle which is acceptable for the animal and convenient for local application to the skin, preferably localized over a small surface area.
76 Citations
70 Claims
- 1. A synergistic spot-on composition for the long lasting protection against fleas and ticks on mammals which comprises synergistic effective amounts of Fipronil synergistic amount of a compound which mimics juvenile hormones and at least one customary spot-on formulation adjuvant.
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5. A synergistic spot-on composition for long-lasting protection against fleas on mammals comprising synergistic amounts of at least one compound (A) of the formula ##STR2## in which:
- R1 is CN or methyl or a halogen atom;
R2 is S(O)n R3 or 4,5-dicyanoimidazol-2-yl or haloalkyl; R3 is alkyl or haloalkyl; R4 represents a hydrogen or halogen atom;
or a radical NR5 R6, S(O)m R7, C(O)R7, C(O)O--R-7, alkyl, haloalkyl or OR8 or a radical --N═
C(R9) (R10);R5 and R6 independently represent a hydrogen atom or an alkyl, haloalkyl, C(O)alkyl, alkoxycarbonyl or S(O)r --CF3 radical;
R6 and R6 may together form a divalent alkylene radical which may be interrupted by one or two divalent hetero atoms;R7 represents an alkyl or haloalkyl radical; R8 represents an alkyl or haloalkyl radical or a hydrogen atom; R10 represents a phenyl or heteroaryl group optionally substituted with one or more halogen atoms or groups such as OII, --O-alkyl, S-alkyl, cyano or alkyl; R11 and R12 represent, independently of each other, a hydrogen or halogen atom, or optionally CN or NO2 ; R13 represents a halogen atom or a haloalkyl, haloalkoxy, S(O)q CF3 or SF5 group; m, n, q and r represent, independently of each other, an integer equal to 0, 1 or 2; X represents a trivalent nitrogen atom or a radical C--R12, the other three valency positions of the carbon atom forming part of the aromatic ring; with the proviso that when R1 is methyl, then R3 is haloalkyl, R4 is NH2, R11 is Cl, R13 is CF3 and X is N;
or R2 is 4,5-dicyanoimidazol-2-yl, R4 is Cl, R11 is Cl, R13 is CF3 and X is ═
C--Cl;a synergistic amount of at least one ovicidal compound (B), of insect growth regulator (IGR) type, in a fluid vehicle which is acceptable to the animal and suitable for local application to the skin; and
at least one customary spot-on formulation adjuvant. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
- R1 is CN or methyl or a halogen atom;
Specification
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Litigation Data
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Current AssigneeMerial
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Original AssigneeMerial
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InventorsJeannin, Philippe
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Primary Examiner(s)CLARDY, S
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Application NumberUS08/863,692Time in Patent Office1,162 DaysField of Search424/405, 514/875, 514/407US Class Current424/405CPC Class CodesA01N 2300/00 Combinations or mixtures of...A01N 25/00 Biocides, pest repellants o...A01N 25/02 containing liquids as carri...A01N 37/28 containing the group; Thio ...A01N 43/28 with two hetero atoms in po...A01N 43/40 six-membered ringsA01N 43/56 1,2-Diazoles; Hydrogenated ...A01N 43/58 1,2-Diazines; Hydrogenated ...A01N 43/68 with two or three nitrogen ...A01N 43/90 having two or more relevant...A01N 47/02 the carbon atom having no b...A01N 47/12 containing a —O—CO—N< group...A01N 47/34 containing the groups , e.g...A01N 49/00 Biocides, pest repellants o...A01N 61/00 Biocides, pest repellants o...A01N 65/00 Biocides, pest repellants o...A61P 33/14 Ectoparasiticides, e.g. sca...
