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Methods of cleaving DNA with rationally-designed meganucleases

DC
  • US 8,163,514 B2
  • Filed: 09/27/2011
  • Issued: 04/24/2012
  • Est. Priority Date: 10/18/2005
  • Status: Active Grant
First Claim
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1. A method of cleaving a target recognition site in double-stranded DNA in a non-human cell or an isolated human cell, wherein said target recognition site has a sequence that differs by at least one nucleotide modification from the wild-type I-CreI meganuclease recognition sequence of SEQ ID NO:

  • 4;

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