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Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same

  • US 8,192,752 B2
  • Filed: 11/21/2003
  • Issued: 06/05/2012
  • Est. Priority Date: 11/21/2003
  • Status: Expired due to Fees
First Claim
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1. A medical article comprising an implantable substrate having a coating, the coating comprising a first biologically erodable polymer having a glass transition temperature below about −

  • 50°

    C. and a biologically erodable polymeric additive mixed with the first polymer, wherein;

    the polymeric additive has a degree of crystallinity greater than that of the first polymer and has a glass transition temperature of about −

    50°

    C. or greater;

    the first polymer is selected from poly(esters), poly(caprolactone), poly(4-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and mixtures thereof; and

    the polymeric additive is selected from poly(L-lactide), poly(L-lactide-co-D,L-lactide), poly(glycolide), poly(glycolide-co-L-lactide), poly(caprolactone-co-L-lactide), poly(caprolactone-co-D,L-lactide), copolymers of trimethylene carbonate, and mixtures thereof.

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