Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same
First Claim
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1. A medical article comprising an implantable substrate having a coating, the coating comprising a first biologically erodable polymer having a glass transition temperature below about −
- 50°
C. and a biologically erodable polymeric additive mixed with the first polymer, wherein;
the polymeric additive has a degree of crystallinity greater than that of the first polymer and has a glass transition temperature of about −
50°
C. or greater;
the first polymer is selected from poly(esters), poly(caprolactone), poly(4-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and mixtures thereof; and
the polymeric additive is selected from poly(L-lactide), poly(L-lactide-co-D,L-lactide), poly(glycolide), poly(glycolide-co-L-lactide), poly(caprolactone-co-L-lactide), poly(caprolactone-co-D,L-lactide), copolymers of trimethylene carbonate, and mixtures thereof.
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Abstract
A medical article comprising an implantable substrate having a coating is disclosed, the coating comprising a biologically erodable polymer having the glass transition temperature below about −50° C. The biologically erodable polymer can be blended with a polymeric additive which either has the glass transition temperature of about −50° C. or higher, or a degree of crystallinity greater than that of the first polymer.
310 Citations
27 Claims
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1. A medical article comprising an implantable substrate having a coating, the coating comprising a first biologically erodable polymer having a glass transition temperature below about −
- 50°
C. and a biologically erodable polymeric additive mixed with the first polymer, wherein;the polymeric additive has a degree of crystallinity greater than that of the first polymer and has a glass transition temperature of about −
50°
C. or greater;the first polymer is selected from poly(esters), poly(caprolactone), poly(4-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and mixtures thereof; and the polymeric additive is selected from poly(L-lactide), poly(L-lactide-co-D,L-lactide), poly(glycolide), poly(glycolide-co-L-lactide), poly(caprolactone-co-L-lactide), poly(caprolactone-co-D,L-lactide), copolymers of trimethylene carbonate, and mixtures thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 26)
- 50°
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14. A method for fabricating a medical article, the method including depositing a coating on at least a portion of an implantable substrate, the coating including a first biologically erodable polymer having a glass transition temperature below about −
- 50°
C. and a biologically erodable polymeric additive mixed with the first polymer, wherein;the polymeric additive has a degree of crystallinity greater than that of the first polymer and has a glass transition temperature of about −
50°
C. or greater;the first polymer is selected from poly(esters), poly(caprolactone), poly(4-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and mixtures thereof; and the polymeric additive is selected from poly(L-lactide), poly(L-lactide-co-D, L-lactide), poly(glycolide), poly(glycolide-co-L-lactide), poly(caprolactone-co-L-lactide), poly(caprolactone-co-D,L-lactide), copolymers of trimethylene carbonate, and mixtures thereof. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27)
- 50°
Specification