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Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant

  • US 8,202,688 B2
  • Filed: 11/20/2002
  • Issued: 06/19/2012
  • Est. Priority Date: 03/10/1997
  • Status: Expired due to Term
First Claim
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1. A method for inducing an immune response against hepatitis virus comprising:

  • administering to a subject infected with hepatitis virus, a synthetic oligonucleotide having a sequence including at least the following formula;


    5′

    X1X2CGX3X43′

    wherein the oligonucleotide is 8 to 100 nucleotides in length wherein C is unmethylated and wherein X1X2 and X3X4 are nucleotides, wherein the oligonucleotide is SEQ ID NO. 77, in an effective amount to produce an immune response against the hepatitis virus, and further comprising administering an antigen and a non-nucleic acid adjuvant, wherein the oligonucleotide and the non-nucleic acid adjuvant are administered in an amount specific for inducing a synergistic antigen-specific immune response.

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