Hyperspectral imaging in diabetes and peripheral vascular disease
First Claim
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1. A medical instrument comprising:
- a first stage optic configured to receive light from tissue of a subject in a region of interest;
a spectral separator configured to filter the received light;
an imaging sensor configured to receive filtered light from the spectral separator and to generate an image of the region of interest based on the filtered light;
a diagnostic protocol module; and
a diagnostic processor configured to;
instruct the spectral separator to filter the received light into a plurality of spectral bands based on the diagnostic protocol module,instruct the imaging sensor to record a plurality of images of the region of interest based on the diagnostic protocol module, each image of the plurality of images corresponding to a spectral band of the plurality of spectral bands,obtain a hyperspectrally resolved image based on the plurality of images, wherein each image in the plurality of images comprises a plurality of pixels,co-register corresponding pixels in each image in the plurality of images to derive an oxyhemoglobin concentration and a deoxyhemoglobin concentration from each set of co-registered pixels in the plurality of images, andobtain a pseudo-color image based on the hyperspectrally resolved image, wherein the pseudo-color image comprises;
(i) a color hue plane that represents a first characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration,(ii) a color saturation plane that represents a second characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration, with the proviso that the second characteristic is other than the first characteristic, and(iii) a color intensity plane that represents reflectance in a region that is about 450 nm to about 580 nm.
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Abstract
The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.
76 Citations
20 Claims
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1. A medical instrument comprising:
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a first stage optic configured to receive light from tissue of a subject in a region of interest; a spectral separator configured to filter the received light; an imaging sensor configured to receive filtered light from the spectral separator and to generate an image of the region of interest based on the filtered light; a diagnostic protocol module; and a diagnostic processor configured to; instruct the spectral separator to filter the received light into a plurality of spectral bands based on the diagnostic protocol module, instruct the imaging sensor to record a plurality of images of the region of interest based on the diagnostic protocol module, each image of the plurality of images corresponding to a spectral band of the plurality of spectral bands, obtain a hyperspectrally resolved image based on the plurality of images, wherein each image in the plurality of images comprises a plurality of pixels, co-register corresponding pixels in each image in the plurality of images to derive an oxyhemoglobin concentration and a deoxyhemoglobin concentration from each set of co-registered pixels in the plurality of images, and obtain a pseudo-color image based on the hyperspectrally resolved image, wherein the pseudo-color image comprises; (i) a color hue plane that represents a first characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration, (ii) a color saturation plane that represents a second characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration, with the proviso that the second characteristic is other than the first characteristic, and (iii) a color intensity plane that represents reflectance in a region that is about 450 nm to about 580 nm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 16, 17)
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10. A method for assessing a pressure ulcer or a risk of pressure ulcer, the method comprising:
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receiving light from tissue of a subject in a region of interest; filtering the received light into a plurality of spectral bands based on a diagnostic protocol module adapted to assess in tissue a pressure ulcer or a risk of pressure ulcer; recording a plurality of images of the region of interest based on the diagnostic protocol module, each image of the plurality of images corresponding to a spectral band of the plurality of spectral bands; obtaining a hyperspectrally resolved image based on the plurality of images, wherein each image in the plurality of images comprises a plurality of pixels; and co-registering corresponding pixels in each image in the sequence of images to derive a coefficient for oxyhemoglobin and a coefficient for deoxyhemoglobin from each set of co-registered pixels in the plurality of images obtaining a pseudo-color image based on the hyperspectrally resolved image, the pseudo-color image indicating a presence of a pressure ulcer or a risk of pressure ulcer in the region of interest, wherein the pseudo-color image comprises; (i) a color hue plane that represents a first characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration, (ii) a color saturation plane that represents a second characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration, with the proviso that the second characteristic is other than the first characteristic, and (iii) a color intensity plane that represents reflectance in a region that is about 450 nm to about 580 nm. - View Dependent Claims (11, 12, 13, 14, 15, 18, 19, 20)
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Specification
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Current AssigneeHypermed Imaging Incorporated
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Original AssigneeHypermed Imaging Incorporated
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InventorsFreeman, Jenny, Panasyuk, Svetlana, Hopmeier, Michael, Schomacker, Kevin, Brand, Derek
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Primary Examiner(s)Chen, Tse
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Assistant Examiner(s)Luong, Peter
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Application NumberUS11/689,783Publication NumberTime in Patent Office1,944 DaysField of Search600/310, 600/320, 600/407, 600/473, 600/476, 382/167, 382/274US Class Current600/473CPC Class CodesA61B 2560/0228 using calibration standardsA61B 5/0059 using light, e.g. diagnosis...A61B 5/14551 for measuring blood gasesA61B 5/412 Detecting or monitoring sepsisA61B 5/445 Evaluating skin irritation ...
