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Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy

DC
  • US 8,324,275 B2
  • Filed: 04/13/2012
  • Issued: 12/04/2012
  • Est. Priority Date: 12/23/1998
  • Status: Expired due to Fees
First Claim
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1. A method of treating cataplexy or daytime sleepiness in a patient who has been diagnosed with narcolepsy, comprising:

  • (i) diluting an aqueous solution comprising about 500 mg/mL of sodium gamma-hydroxybutyrate with an aqueous medium to provide a first dose of about 4.5 to about 9 grams sodium gamma-hydroxybutyrate;

    (ii) diluting an aqueous solution comprising about 500 mg/mL of sodium gamma-hydroxybutyrate with an aqueous medium to provide a second dose of about 4.5 to about 9 grams of sodium gamma-hydroxybutyrate;

    (iii) orally administering to a patient having narcolepsy the first dose within an hour prior to initial sleep onset; and

    (iv) orally administering to the patient having narcolepsy the second dose within 2.5 to 4 hours following initial sleep onset.

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