Method for obtaining aqueous formulations of oxidation-sensitive active principles
First Claim
1. A method for preparing an aqueous solution with an active principle of a phenolic nature susceptible to oxidation, while preserving for a prolonged period, characterized in that use is made of deoxygenation of the solution by bubbling with at least one inert gas and/or placing under vacuum, until the oxygen content is below 2 ppm, in that the aforementioned aqueous solution with an active principle is possibly topped with an inert gas atmosphere and placed in a closed container in which the prevailing pressure is 65,000 Pa maximum, in that the oxygen content of the aqueous solution is below or equal to 2 ppm, and in that the effect of the deoxygenation of the solution is completed by addition of an antioxidant.
3 Assignments
0 Petitions
Accused Products
Abstract
A water cooled exhaust tube, especially for boats, comprises an outer housing (3) formed as a tube, an inner tube (1) extending coaxially in the housing, at a radial distance from the latter, and a cam (7), extending in a screw line shaped manner in the longitudinal direction of the housing, spanning the distance between the housing (3) and the inner tube (1) and forming a channel (11), extending in a screw line shaped manner between the housing (3) and the inner tube (1). The inner tube (1) conducts the exhausts gases while the channel (11) conducts cooling water separately from the exhaust gases. The exhaust tube is flexible since all parts are made in rubber. In the inner tube (1) silencing means (17) can be arranged to from a silencer. The inner tube (1) is adapted to be replaceable int he outer housing (3) and can be a rubber hose.
42 Citations
23 Claims
- 1. A method for preparing an aqueous solution with an active principle of a phenolic nature susceptible to oxidation, while preserving for a prolonged period, characterized in that use is made of deoxygenation of the solution by bubbling with at least one inert gas and/or placing under vacuum, until the oxygen content is below 2 ppm, in that the aforementioned aqueous solution with an active principle is possibly topped with an inert gas atmosphere and placed in a closed container in which the prevailing pressure is 65,000 Pa maximum, in that the oxygen content of the aqueous solution is below or equal to 2 ppm, and in that the effect of the deoxygenation of the solution is completed by addition of an antioxidant.
Specification
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- Resources
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Current AssigneeNew Pharmatop L.P., Pharmatop Scr
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Original AssigneePharmatop Scr
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InventorsFredj, Daniele, Dietlin, Francois
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current514/646
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CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/05 Phenols cannabinoids A61K31...A61K 31/136 having the amino group dire...A61K 31/167 having the nitrogen of a ca...A61K 31/375 Ascorbic acid, i.e. vitamin...A61K 33/00 Medicinal preparations cont...A61K 45/06 Mixtures of active ingredie...A61K 47/12 Carboxylic acids; Salts or ...A61K 47/22 Heterocyclic compounds, e.g...A61K 9/0019 Injectable compositions; In...A61K 9/08 Solutions composition of so...B01D 19/0005 with one or more auxiliary ...
