Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same

US 20050112171A1
Filed: 11/21/2003
Published: 05/26/2005
Est. Priority Date: 11/21/2003
Status: Active Grant

First Claim

Patent Images

1. A medical article comprising an implantable substrate having a coating, the coating comprising a first biologically erodable polymer having the glass transition temperature below about −

50°

C.

View all claims

1 Assignment

Timeline View

Assignment View

0 Petitions

Accused Products

Abstract

A medical article comprising an implantable substrate having a coating is disclosed, the coating comprising a biologically erodable polymer having the glass transition temperature below about −50° C. The biologically erodable polymer can be blended with a polymeric additive which either has the glass transition temperature of about −50° C. or higher, or a degree of crystallinity greater than that of the first polymer.

214 Citations

32 Claims

1. A medical article comprising an implantable substrate having a coating, the coating comprising a first biologically erodable polymer having the glass transition temperature below about −
- 50°
  
  C.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 21)
- - 2. The medical article of claim 1, wherein the first polymer includes poly(esters).
  - 3. The medical article of claim 1, wherein the first polymer is poly(caprolactone).
  - 4. The medical article of claim 1, wherein the first polymer is selected from a group consisting of poly(4-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and mixtures thereof.
  - 5. The medical article of claim 1, additionally including a biologically erodable polymeric additive mixed with the first polymer, wherein the additive is a polymer having the glass transition temperature of about −
    - 50°
      
      C. or greater.
  - 6. The medical article of claim 1, wherein the additive is a polymer having the glass transition temperature between about −
    - 50°
      
      C. and about 80°
      
      C.
  - 7. The medical article of claim 1, wherein the additive is a polymer having the glass transition temperature between about −
    - 20°
      
      C. and about 40°
      
      C.
  - 8. The medical article of claim 1, wherein the additive is a polymer having the glass transition temperature between about 0°
    - C. and about 20°
      
      C.
  - 9. The medical article of claim 1, additionally including a biologically erodable polymeric additive mixed with the first polymer, wherein the additive is a polymer having a degree of crystallinity greater than that of the first polymer.
  - 10. The medical article of claim 1, additionally including a biologically erodable polymeric additive mixed with the first polymer, wherein the additive is selected from a group consisting of poly(3-hydroxybutyrate), poly(L-lactide), poly(D,L-lactide), poly(L-lactide-co-D,L-lactide), poly(glycolide), poly(glycolide-co-L-lactide), poly(glycolide-co-D,L-lactide), poly(caprolactone-co-L-lactide), poly(caprolactone-co-D,L-lactide), poly(trimethylene carbonate), copolymers of trimethylenecarbonate, poly(orthoesters), tyrosine derived poly(carbonates), poly(iminocarbonates), poly(ester-amides), and mixtures thereof.
  - 11. The medical article of claim 1, wherein the medical article is a stent.
  - 12. The medical article of claim 1, wherein the mass ratio between the first polymer and the polymeric additive is between about 9:
    - 1 and about 0.16;
      
      1.
  - 13. The medical article of claim 1, wherein the mass ratio between the first polymer and the polymeric additive is between about 6:
    - 1 and about 0.25;
      
      1.
  - 14. The medical article of claim 1, wherein the mass ratio between the first polymer and the polymeric additive is between about 3:
    - 1 and about 0.33;
      
      1.
  - 15. The medical article of claim 1, wherein the coating additionally comprises a therapeutic substance.
  - 16. The medical article of claim 1, wherein the coating is a topcoat layer disposed over a drug reservoir layer for reducing the rate of release of a drug from the reservoir layer.
  - 21. The medical article of claim 1, wherein the first polymer is selected from a group consisting of poly(4-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and mixtures thereof.

17. A method for fabricating a medical article, the method including depositing a coating on at least a portion of an implantable substrate, the coating including a first biologically erodable polymer having the glass transition temperature below about −
- 50°
  
  C.
- View Dependent Claims (18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
- - 18. The method of claim 17, wherein the first polymer includes poly(esters).
  - 19. The method of claim 17, wherein the first polymer includes poly(esters).
  - 20. The method of claim 17, wherein the first polymer is poly(caprolactone).
  - 22. The method of claim 17, additionally mixing a biologically erodable polymeric additive mixed with the first polymer, wherein the additive is a polymer having the glass transition temperature of about −
    - 50°
      
      C. or greater.
  - 23. The method of claim 17, wherein the additive is a polymer having the glass transition temperature between about −
    - 50°
      
      C. and about 80°
      
      C.
  - 24. The method of claim 17, wherein the additive is a polymer having the glass transition temperature between about −
    - 20°
      
      C. and about 40°
      
      C.
  - 25. The method of claim 17, wherein the additive is a polymer having the glass transition temperature between about 0°
    - C. and about 20°
      
      C.
  - 26. The method of claim 17, additionally mixing a biologically erodable polymeric additive mixed with the first polymer, wherein the additive is a polymer having a degree of crystallinity greater than that of the first polymer.
  - 27. The method of claim 17, additionally mixing a biologically erodable polymeric additive mixed with the first polymer, wherein the additive is selected from a group consisting of poly(3-hydroxybutyrate), poly(L-lactide), poly(D,L-lactide), poly(L-lactide-co-D,L-lactide), poly(glycolide), poly(glycolide-co-L-lactide), poly(glycolide-co-D,L-lactide), poly(caprolactone-co-L-lactide), poly(caprolactone-co-D,L-lactide), poly(trimethylene carbonate), copolymers of trimethylenecarbonate, poly(orthoesters), tyrosine derived poly(carbonates), poly(iminocarbonates), poly(ester-amides), and mixtures thereof.
  - 28. The method of claim 17, wherein the medical article is a stent.
  - 29. The medical article of claim 17, wherein the mass ratio between the first polymer and the polymeric additive is between about 9:
    - 1 and about 0.16;
      
      1.
  - 30. The method of claim 17, wherein the mass ratio between the first polymer and the polymeric additive is between about 6:
    - 1 and about 0.25;
      
      1.
  - 31. The method of claim 17, wherein the mass ratio between the first polymer and the polymeric additive is between about 3:
    - 1 and about 0.33;
      
      1.
  - 32. The method of claim 17, wherein the coating additionally including incorporating a therapeutic substance in the coating.

Specification

Resources

Litigation Campaign Assessment

Current Assignee
Advanced Cardiovascular Systems Incorporated
Original Assignee
Advanced Cardiovascular Systems Incorporated
Inventors
Tang, Yiwen, Pacetti, Stephen D.

Granted Patent

US 8,192,752 B2
Time in Patent Office

Days
Field of Search
US Class Current

424/423
CPC Class Codes

A61F 2/86   Stents in a form characteri...

A61L 2300/606   Coatings

A61L 2420/08   Coatings comprising two or ...

A61L 31/10   Macromolecular materials

A61L 31/148   Materials at least partiall...

A61L 31/16   Biologically active materia...

C08L 67/04   Polyesters derived from hyd...

Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same

First Claim

1 Assignment

0 Petitions

Accused Products

Abstract

214 Citations

32 Claims

Specification

Solutions

Use Cases

Quick Links

Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same

First Claim

1 Assignment

Subscription Required

Subscription Required

0 Petitions

Subscription Required

Accused Products

Subscription Required

Abstract

214 Citations

32 Claims

Specification

Subscription Required

Solutions

Use Cases

Quick Links