Multi-Phase Contraceptive Preparation Based on a Natural Estrogen
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Accused Products
Abstract
The multiphase preparation having higher contraceptive safety and reduced side effects is based on a combination of a natural oestrogen with dienogest or drospirenon. The multiphase preparation is characterized by a first phase consisting of 2 daily dose units of 3 mg of oestradiol valerate, a second phase consisting of 2 groups of daily dose units, wherein a first group is formed by 5 daily dose units each containing a combination of 2 mg of oestradiol valerate and at least two or three times an ovulation-inhibitory dose of dienogest or drospirenon and a second group is formed by 17 daily dose units each containing a combination of 2 mg of oestradiol valerate and at least three or four times the ovulation-inhibitory dose of dienogest or drospirenon, a third phase consisting of 2 daily dose units of 1 mg of oestradiol valerate, and a further phase consisting of 2 daily dose units of pharmaceutically acceptable placebo.
38 Citations
3 Claims
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1-2. -2. (canceled)
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3. A multiphase product for contraception based on a natural oestrogen and a synthetic progestogen;
- said multiphase product characterized in that
a first phase consists of 2 daily dose units of 3 mg of oestradiol valerate, a second phase consists of 2 groups of daily dose units, wherein a first group is formed by 5 daily dose units each consisting of a combination of 2 mg of said oestradiol valerate and at least two or three times an ovulation-inhibitory dose of dienogest or drospirenon and a second group is formed by 17 daily dose units each consisting of a combination of 2 mg of said oestradiol valerate and at least three or four times the ovulation-inhibitory dose of said dienogest or drospirenon, a third phase consists of 2 daily dose units of 1 mg of said oestradiol valerate, and a further phase consists of 2 daily dose units of pharmaceutically acceptable placebo.
- said multiphase product characterized in that
Specification