NOVEL ANTIFOLATE COMBINATION THERAPIES
0 Assignments
0 Petitions
Accused Products
Abstract
A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
13 Citations
39 Claims
-
1-28. -28. (canceled)
-
29. An improved method for administering pemetrexed disodium to a patient in need of chemotherapeutic treatment, wherein the improvement comprises:
-
a) administration of between 350 μ
g and 1000 μ
g of folic acid, daily beginning approximately 1 to 3 weeks before treatment with pemetrexed disodium;
b) administration of a methylmalonic acid lowering agent selected from the group consisting of vitamin B12, hydroxocobalamin, cyano-10-chlorocobalamin, aquocobalamin perchlorate, aquo-10-chlorocobalamin perchlorate, azidocobalamin, chlorocobalamin and cobalamin, wherein the methylmalonic acid lowering agent is administered from about 1 to about 3 weeks prior to the first administration of pemetrexed disodium; and
c) administration of pemetrexed disodium in combination with between 350 μ
g and 100 μ
g of folic acid, daily, until administration of pemetrexed disodium is discontinued, and a methylmalonic acid lowering agent selected from the group consisting of vitamin B12, hydroxocobalamin, cyano-10-chlorocobalamin, aquocobalamin perchlorate, aquo-10-chlorocobalamin perchlorate, azidocobalamin, chlorocobalamin and cobalamin, wherein the methylmalonic acid lowering agent administration is repeated from about every 6 weeks to about every 12 weeks, until administration of pemetrexed disodium is discontinued. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
-
-
39. An improved method for administering pemetrexed disodium to a patient in need of chemotherapeutic treatment, wherein the improvement comprises:
-
a) administration of between 350 μ
g and 1000 μ
g of folic acid, daily beginning approximately 1 to 3 weeks before treatment with pemetrexed disodium;
b) administration of a methylmalonic acid lowering agent selected from the group consisting of vitamin B12, hydroxocobalamin, cyano-10-chlorocobalamin, aquocobalamin perchlorate, aquo-10-chlorocobalamin perchlorate, azidocobalamin, chlorocobalamin and cobalamin, wherein the methylmalonic acid lowering agent is administered from about 1 to about 3 weeks prior to the first administration of pemetrexed disodium; and
c) administration of pemetrexed disodium in combination with between 350 μ
g and 1000 μ
g of folic acid, daily, until administration of pemetrexed disodium is discontinued, and a methylmalonic acid lowering agent selected from the group consisting of vitamin B12, hydroxocobalamin, cyano-10-chlorocobalamin, aquocobalamin perchlorate, aquo-10-chlorocobalamin perchlorate, azidocobalamin, chlorocobalamin and cobalamin, wherein the methylmalonic acid lowering agent is administered by an intramuscular injection and wherein administration is repeated from about every 24 hours to about every 1680 hours, until administration of pemetrexed disodium is discontinued.
-
Specification