RAPID DISSOLUTION FORMULATION OF A CALCIUM RECEPTOR-ACTIVE COMPOUND
First Claim
1. A pharmaceutical composition comprising an effective dosage amount of a calcium receptor-active compound and at least one pharmaceutically acceptable excipient,wherein at least one dosage unit of the composition has a dissolution profile in 0.05 N HCl, measured according to a dissolution test conducted in a USP 2 apparatus at a temperature of about 37°
- C., and at a rotation speed of about 75 r.p.m., which comprises from about 50% to about 125% of a target amount of the calcium receptor-active compound being released from the composition no later than about 30 minutes from the start of the test.
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Accused Products
Abstract
The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a calcium receptor-active compound and at least one pharmaceutically acceptable excipient, wherein the composition has a controlled dissolution profile. The present invention further relates to a method of manufacturing the pharmaceutical composition, as well as a method of treating a disease using the pharmaceutical composition.
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Citations
1 Claim
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1. A pharmaceutical composition comprising an effective dosage amount of a calcium receptor-active compound and at least one pharmaceutically acceptable excipient,
wherein at least one dosage unit of the composition has a dissolution profile in 0.05 N HCl, measured according to a dissolution test conducted in a USP 2 apparatus at a temperature of about 37° - C., and at a rotation speed of about 75 r.p.m., which comprises from about 50% to about 125% of a target amount of the calcium receptor-active compound being released from the composition no later than about 30 minutes from the start of the test.
Specification
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- Resources
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Current AssigneeAmgen Inc.
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Original AssigneeAmgen Inc.
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InventorsLin, Hung-Ren H., Alvarez, Francisco J., Ju, Tzuchi R., LAWRENCE, Glen Gary
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current514/654
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CPC Class CodesA61K 31/00 Medicinal preparations cont...A61K 31/135 having aromatic rings , e.g...A61K 31/137 Arylalkylamines, e.g. amphe...A61K 9/2077 Tablets comprising drug-con...A61K 9/2866 Cellulose; Cellulose deriva...A61P 3/00 Drugs for disorders of the ...A61P 3/14 for calcium homeostasis vit...A61P 43/00 Drugs for specific purposes...A61P 5/00 Drugs for disorders of the ...A61P 5/18 of the parathyroid hormonesA61P 5/20 for decreasing, blocking or...
