USE OF PHOSPHORDIESTERASE INHIBITORS IN THE TREATMENT OF PROSTATIC DISEASES
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Accused Products
Abstract
The present invention pertains to the use of inhibitors of phosphodiesterase I, IV and V for the prophylaxis and treatment of prostatic diseases, in particular the use of
- a) 2-(2-propoxy- phenyl)-8-azapurin-6-one (zaprinast);
- b) dipyridamole;
- c) 1-(3-chlorophenylamino)-4-phenylphthalazine (M5445);
- d) 2-(N-(4-carboxypiperidine-6-chloro-4-(3,4-(methylendioxy)benzyl)amino)quinazoline (E 4021, ER 21355);
- e) 2,3-dihydro-8-hydroxy-7-nitro-1,4-benzodioxine-2-methanol, alpha-nitrate (E 4701);
- f) 4-((3,4-(methylendioxy)benzyl)amino)-6,7,8-trimethoxy-quinazoline;
- g) 1-methly-3-propyl-6-(5-(N-(4-methylmorpholino)sulfonyl)-2-ethoxyphenyl)pyrazole[4,5]pyrimidin-4(5H)one (sildenafil);
- i) 1-cyclopentyl-3-methyl-6-(4-pyridinyl)pyrazolo(3,4-d)pyrimidin-4(5H)-one (WIN 58237);
- j) 7-(3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxypropoxy)-2-carboxy-2,3-didehydro-chronan-4-one (PPL-557212);
- k). quinazolines and their trimethoxy derivatives;
- l) Pyrazolopyrimidones;
- as well as pharmacologically compatible salts thereof,
- quinazolines and their trimethoxy derivatives, pyrazolopyrimidones or compatible salts thereof, in local and systemic administration.
3 Citations
16 Claims
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1-8. -8. (canceled)
- 9. A medicament useful in the treatment of prostatic disease comprising an inhibitor agent of PDE IV and/or PDE V, excluding 1-(3-chlorophenylamino)4-phenylphthalazine (MY5445);
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10. A medicament useful in the treatment of prostatic disease comprising an active component selected from the group consisting of:
a) 2-(2-propoxyphenyl)-8-azapurin-6-one (zaprinast); - View Dependent Claims (15)
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16. A method of treating a prostatic disease selected from the group consisting of benign prostatic hyperplasia, urge symptoms, pollacuria, nycturia, weakened urine jet, urge incontinence, prostatism, instabilities of the bladder muscles, and impotence, comprising administering to a patient an effective amount of a medicament comprising 1-(3-chlorophenylamino)4-phenylphthalazine (MY5445);
Specification
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Current AssigneeErfindergemeinschaft Uropep Gbr, Uropep Biotech GBR
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Original AssigneeUropep Biotech GBR
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InventorsForssmann, Wolf-Georg, Steif, Christian Georg, Uckert, Stefan, Jonas, Udo, Truß, Michael Carsten
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current514/248
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CPC Class CodesA61K 31/4162 condensed with heterocyclic...A61K 31/4174 Arylalkylimidazoles, e.g. o...A61K 31/445 Non condensed piperidines, ...A61K 31/502 ortho- or peri-condensed wi...A61K 31/517 ortho- or peri-condensed wi...A61K 31/519 ortho- or peri-condensed wi...A61K 31/52 Purines, e.g. adenineA61P 13/08 of the prostateA61P 15/10 for impotence
