Tetrahydrofuran antifungals
DC CAFC
First Claim
Patent Images
1. A compound represented by the formula ##STR100## or an ester group thereof convertible in vivo into OH;
- or a pharmaceutically acceptable salt thereof.
2 Assignments
Litigations
0 Petitions
Accused Products
Abstract
A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
49 Citations
13 Claims
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1. A compound represented by the formula ##STR100## or an ester group thereof convertible in vivo into OH;
- or a pharmaceutically acceptable salt thereof.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- 11. A compound represented by the formula ##STR104## or a pharmaceutically acceptable salt thereof.
Specification
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Litigation Data
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Current AssigneeMerck Sharp & Dohme Corporation (Merck & Co., Inc.)
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Original AssigneeSchering Corporation (Merck & Co., Inc.)
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InventorsBennett, Frank, Wang, Haiyan, Girijavallabhan, Viyyoor M., Liu, Yi-Tsung, Ganguly, Ashit K., Saksena, Anil K., Pike, Russell E., Lovey, Raymond G.
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Primary Examiner(s)Bernhardt, Emily
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Application NumberUS08/460,752Time in Patent Office816 DaysField of Search544/366, 544/60, 544/121, 544/337, 544/357, 544/364, 514/252, 514/85, 514/227.8, 514/236.2US Class Current514/254.07CPC Class CodesA61P 31/00 Antiinfectives, i.e. antibi...A61P 31/10 AntimycoticsC07D 231/12 with only hydrogen atoms, h...C07D 233/56 with only hydrogen atoms or...C07D 249/08 1,2,4-Triazoles; Hydrogenat...C07F 9/65586 at least one of the hetero ...
