Sublingual or buccal pharmaceutical composition
DC CAFCFirst Claim
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1. A pharmaceutical composition comprising as a medicinally active compound:
- trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz 2,3;
6,7!oxepino 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof;
wherein the composition is a solid composition and disintegrates within 30 seconds in water at 37°
C.
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Abstract
The invention relates to a sublingual or buccal pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:6,7!oxepino- 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable auxiliaries suitable for use in sublingual or buccal compositions, and the use thereof for the manufacture of a sublingual or buccal pharmaceutical composition for the treatment of mental disorders, such as psychosis and schizophrenia.
56 Citations
13 Claims
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1. A pharmaceutical composition comprising as a medicinally active compound:
- trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz 2,3;
6,7!oxepino 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof;
wherein the composition is a solid composition and disintegrates within 30 seconds in water at 37°
C. - View Dependent Claims (2, 3, 5, 6)
- trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz 2,3;
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4. A method for treating tension, excitation, anxiety, and psychotic and schizophrenic disorders, comprising administering sublingually or buccally an effective amount of a pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:
- 6,7!oxepino 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof.
- View Dependent Claims (9, 10, 11, 12)
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7. A pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:
- 6,7!oxepino 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof; and
pharmaceutically acceptable auxiliaries, wherein the composition is made by the process ofa) providing an aqueous solution comprising said compound and a water soluble or water dispersable carrier material; b) transferring the composition of a) into a mold; c) freezing the composition in the mold; and d) subliming the solvent by freeze-drying.
- 6,7!oxepino 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof; and
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8. A pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:
- 6,7!oxepino 4,5-c!pyrrole maleate, mannitol, and gelatin.
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13. A method for treating antihistamine and antiserotonin related diseases comprising administering sublingually or buccally an effective amount of a pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:
- 6,7!oxepino 4,5-c!pyrrole or a pharmaceutically acceptable salt thereof.
Specification