Taxoids, their preparation and pharmaceutical compositions containing them
DC CAFC
First Claim
Patent Images
1. 4.alpha.-Acetoxy-2α
- -benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7β
,10.beta.-dimethoxy-9-oxo-11-taxen-13α
-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate.
4 Assignments
Litigations
2 Petitions
Accused Products
Abstract
New taxoids of general formula (I): ##STR1## their preparation and pharmaceutical compositions containing them, and the new products of general formula (I) in which Z represents a radical of general formula (II): ##STR2## display noteworthy antitumour and antileukaemic properties.
55 Citations
22 Claims
-
1. 4.alpha.-Acetoxy-2α
- -benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7β
,10.beta.-dimethoxy-9-oxo-11-taxen-13α
-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate. - View Dependent Claims (2, 11)
- -benzoyloxy-5β
-
3. A method comprising the step of etherifying selectively at position 7 a compound of the formula (XIV):
- ##STR23## wherein R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain,
with a compound of the formula (XV);
space="preserve" listing-type="equation">R'"'"'.sub.5 --X.sub.2 (XV)wherein R'"'"'5 represents a radical such that R'"'"'5 --O represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain and X2 represents a reactive ester residue or a halogen atom, to produce a compound of the formula (I);
##STR24## wherein Z is hydrogen, R4 is as defined above, and R5 is identical to R'"'"'5 as defined above.
- ##STR23## wherein R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain,
-
4. A method comprising the step of reacting a product of the formula (XV):
-
space="preserve" listing-type="equation">R'"'"'.sub.5 --X.sub.2 (XV)wherein R'"'"'5 represents a radical such that R'"'"'5 --O represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain, and X2 represents a reactive ester residue or a halogen atom, with a compound of the formula (XIX);
##STR25## wherein R1 represents a benzoyl radical optionally substituted with one or more identical or different atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and trifluoromethyl radicals,a thenoyl radical, a furoyl radical, or a radical R2 --O--CO-- in which R2 represents; an alkyl radical containing 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, an alkynyl radical containing 3 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 10 carbon atoms, these radicals being optionally substituted with one or more substituents selected from halogen atoms;
hydroxyl radicals;
alkoxy radicals containing 1 to 4 carbon atoms;
dialkylamino radicals in which each alkyl portion contains 1 to 4 carbon atoms;
piperidino radicals;
morpholino radicals;
1-piperazinyl radicals optionally substituted at position 4 with an alkyl radical containing 1 to 4 carbon atoms or with a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms;
cycloalkyl radicals containing 3 to 6 carbon atoms;
cycloalkenyl radicals containing 4 to 6 carbon atoms;
phenyl radicals optionally substituted with one or more atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms;
cyano radicals;
carboxyl radicals; and
alkoxycarbonyl radicals in which the alkyl portion contains 1 to 4 carbon atoms,a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms;
alkyl radicals containing 1 to 4 carbon atoms; and
alkoxy radicals containing 1 to 4 carbon atoms,a 5-membered aromatic heterocyclic radical, or a saturated heterocyclic radical containing 4 to 6 carbon atoms, optionally substituted with one or more alkyl radicals containing 1 to 4 carbon atoms, R3 represents an unbranched or branched alkyl radical containing 1 to 8 carbon atoms, an unbranched or branched alkenyl radical containing 2 to 8 carbon atoms, an unbranched or branched alkynyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, alkylthio, aryloxy, arylthio, hydroxyl, hydroxyalkyl, mercapto, formyl, acyl, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, ora 5-membered aromatic heterocycle containing one or more identical or different hetero atoms selected from nitrogen, oxygen and sulphur atoms and optionally substituted with one or more identical or different substituents selected from halogen atoms, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxycarbonylamino, acyl, arylcarbonyl, cyano, carboxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl and alkoxycarbonyl radicals, with the proviso that, in the substituents of the phenyl, α
- or β
-naphthyl and aromatic heterocyclic radicals in the definitions of R2 and R3, the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms, and the alkenyl and alkynyl radicals contain 2 to 8 carbon atoms, and the aryl radicals are phenyl or α
- or β
-naphthyl radicals,R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain either R6 represents a hydrogen atom and R7 represents a group protecting the hydroxyl function, or R6 and R7 together form a saturated 5- or 6-membered heterocycle, to form a compound of the formula (V);
##STR26## wherein R5 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain and R1, R3, R4, R6, and R7 are as defined above.
-
-
5. A method comprising the step of replacing with hydrogen atom(s) group(s) R6 and R7 in a compound of the formula (V):
- ##STR27## wherein;
R1 represents a benzoyl radical optionally substituted with one or more identical or different atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and trifluoromethyl radicals,a thenoyl radical, a furoyl radical, or a radical R2 --O--CO-- in which R2 represents; an alkyl radical containing 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, an alkynyl radical containing 3 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 10 carbon atoms, these radicals being optionally substituted with one or more substituents selected from halogen atoms;
hydroxyl radicals;
alkoxy radicals containing 1 to 4 carbon atoms;
dialkylamino radicals in which each alkyl portion contains 1 to 4 carbon atoms;
piperidino radicals;
morpholino radicals;
1-piperazinyl radicals optionally substituted at position 4 with an alkyl radical containing 1 to 4 carbon atoms or with a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms;
cycloalkyl radicals containing 3 to 6 carbon atoms;
cycloalkenyl radicals containing 4 to 6 carbon atoms;
phenyl radicals optionally substituted with one or more atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms;
cyano radicals;
carboxyl radicals; and
alkoxycarbonyl radicals in which the alkyl portion contains 1 to 4 carbon atoms,a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms;
alkyl radicals containing 1 to 4 carbon atoms; and
alkoxy radicals containing 1 to 4 carbon atoms,a 5-membered aromatic heterocyclic radical, or a saturated heterocyclic radical containing 4 to 6 carbon atoms, optionally substituted with one or more alkyl radicals containing 1 to 4 carbon atoms, R3 represents an unbranched or branched alkyl radical containing 1 to 8 carbon atoms, an unbranched or branched alkenyl radical containing 2 to 8 carbon atoms, an unbranched or branched alkynyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, alkylthio, aryloxy, arylthio, hydroxyl, hydroxyalkyl, mercapto, formyl, acyl, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, ora 5-membered aromatic heterocycle containing one or more identical or different hetero atoms selected from nitrogen, oxygen and sulphur atoms and optionally substituted with one or more identical or different substituents selected from halogen atoms, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxycarbonylamino, acyl, arylcarbonyl, cyano, carboxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl and alkoxycarbonyl radicals, with the proviso that, in the substituents of the phenyl, α
- or β
-naphthyl and aromatic heterocyclic radicals in the definitions of R2 and R3, the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms, and the alkenyl and alkynyl radicals contain 2 to 8 carbon atoms, and the aryl radicals are phenyl or α
- or β
-naphthyl radicals,R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain R5 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain and either R6 represents a hydrogen atom and R7 represents a group protecting the hydroxyl function, or R6 and R7 together form a saturated 5- or 6-membered heterocycle, by treating the compound of formula (V) with an organic or inorganic acid, optionally in an organic solvent to obtain a compound of the formula (VII);
##STR28## wherein R3, R4, and R5 are as defined above.
- ##STR27## wherein;
-
6. A process for the preparation of 4α
- -acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-dimethoxy-9-oxo-11-taxen-13α
-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, said process comprising;converting 4α
-acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-bis(methylthiomethoxy)-9-oxo-11-taxen-13α
-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate to said 4α
-acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-dimethoxy-9-oxo-11-taxen-13α
-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate.
- -acetoxy-2α
-
7. A process for the preparation of 4α
- -acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-dimethoxy-9-oxo-11-taxen-13α
-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, said process comprising;(a) reacting 4α
-acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-7β
,10.beta.-trihydroxy-9-oxo-11-taxen-13α
-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate with dimethyl sulfoxide in the presence of acetic anhydride and acetic acid to obtain 4α
-acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-bis(methylthiomethoxy)-9-oxo-11-taxen-13α
-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate;(b) reacting the product obtained in (a) with activated Raney nickel to obtain 4α
-acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-dimethoxy-9-oxo-11-taxen-13α
-yl (2R,4S,5R)-3-tertbutoxy-carbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate; and(c) reacting the product obtained in (b) with an acid to obtain 4α
-acetoxy-2α
-benzoyloxy-5β
,20-epoxy-1β
-hydroxy-7.beta.,10β
-dimethoxy-9-oxo-11-taxen-13α
-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate. - View Dependent Claims (22)
- -acetoxy-2α
-
8. A process for preparing a taxoid of the following formula (l):
- ##STR29## in which;
Z represents a radical of formula (II);
##STR30## in which;
R1 represents a benzoyl radical optionally substituted with one or more identical or different atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and trifluoromethyl radicals,a thenoyl radical, a furoyl radical, or a radical R2 --O--CO-- in which R2 represents; an alkyl radical containing 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, an alkynyl radical containing 3 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 10 carbon atoms, these radicals being optionally substituted with one or more substituents selected from halogen atoms;
hydroxyl radicals;
alkoxy radicals containing 1 to 4 carbon atoms;
dialkylamino radicals in which each alkyl portion contains 1 to 4 carbon atoms;
piperidino radicals;
morpholino radicals;
1-piperazinyl radicals optionally substituted at position 4 with an alkyl radical containing 1 to 4 carbon atoms or with a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms;
cycloalkyl radicals containing 3 to 6 carbon atoms;
cycloalkenyl radicals containing 4 to 6 carbon atoms;
phenyl radicals optionally substituted with one or more atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms;
cyano radicals;
carboxyl radicals; and
alkoxycarbonyl radicals in which the alkyl portion contains 1 to 4 carbon atoms,a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms;
alkyl radicals containing 1 to 4 carbon atoms; and
alkoxy radicals containing 1 to 4 carbon atoms,a 5-membered aromatic heterocyclic radical, or a saturated heterocyclic radical containing 4 to 6 carbon atoms, optionally substituted with one or more alkyl radicals containing 1 to 4 carbon atoms, R3 represents an unbranched or branched alkyl radical containing 1 to 8 carbon atoms, an unbranched or branched alkenyl radical containing 2 to 8 carbon atoms, an unbranched or branched alkynyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more identical or different atoms or radicals selected from halogen atoms, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, alkylthio, aryloxy, arylthio, hydroxyl, hydroxyalkyl, mercapto, formyl, acyl, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, ora 5-membered aromatic heterocycle containing one or more identical or different hetero atoms selected from nitrogen, oxygen and sulphur atoms and optionally substituted with one or more identical or different substituents selected from halogen atoms, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxycarbonylamino, acyl, arylcarbonyl, cyano, carboxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl and alkoxycarbonyl radicals, with the proviso that, in the substituents of the phenyl, α
- or β
-naphthyl and aromatic heterocyclic radicals in the definitions of R2 and R3, the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms, and the alkenyl and alkynyl radicals contain 2 to 8 carbon atoms, and the aryl radicals are phenyl or α
- or β
-naphthyl radicals,R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain and R5 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain, said process comprising; esterifying a product of formula (III);
##STR31## in which R4 and R5 are defined as above with an acid of formula (IV);
##STR32## in which R1 and R3 are defined as above, and either R6 represents a hydrogen atom and R7 represents a group protecting the hydroxyl function, or R6 and R7 together form a saturated 5- or 6-membered heterocycle, orwith a derivative of said acid, to obtain an ester of formula (V);
##STR33## in which R1, R3, R4, R5, R6 and R7 are defined as above, andreplacing the protective group(s) of said ester of formula (V), represented by R7 or R6 and R7 together, by hydrogen atoms. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- ##STR29## in which;
-
9. A process for preparing a new taxoid of the following formula (I):
- ##STR34## in which;
Z represents a hydrogen atom,R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain and R5 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain, said process comprising; treating 10-deacetylbaccatin III of formula (IX);
##STR35## with a silyl halide of formula;
space="preserve" listing-type="equation">(R).sub.3 --Si--Hal (X)in which the symbols R, which may be identical or different, represent an alkyl radical containing 1 to 6 carbon atoms, optionally substituted with a phenyl radical, a cycloalkyl radical containing 3 to 6 carbon atoms or a phenyl radical, to obtain a product of formula (XI);
##STR36## in which R is defined as above, treating said product of formula (XI) with a product of formula;
space="preserve" listing-type="equation">R'"'"'.sub.4 --X.sub.1 (XII)in which R'"'"'4 represents a radical such that R'"'"'4 --O is identical to R4 defined above and X1 represents a halogen atom or a reactive ester residue, to obtain a product of formula (XIII);
##STR37## in which R and R4 are defined as above, replacing the silyl protective groups of said product of formula (XIII) by hydrogen atoms to obtain a product of formula (XIV);
##STR38## in which R4 is defined as above, and etherifying said compound of formula (XIV) selectively at position 7 with a product of formula (XV);
space="preserve" listing-type="equation">R'"'"'.sub.5 --X.sub.2 (XV)in which R'"'"'5 represents a radical such that R'"'"'5 --O is identical to R5 defined as above and X2 represents a reactive ester residue or a halogen atom, to give the product of formula (I) in which Z represents a hydrogen atom.
- ##STR34## in which;
-
10. A process for preparing a taxoid of the following formula (I):
- ##STR39## in which;
Z represents a radical of formula (II);
##STR40## in which;
R1 represents a benzoyl radical optionally substituted with one or more identical or different atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and trifluoromethyl radicals,a thenoyl radical, a furoyl radical, or a radical R2 --O--CO-- in which R2 represents; an alkyl radical containing 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, an alkynyl radical containing 3 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 10 carbon atoms, these radicals being optionally substituted with one or more substituents selected from halogen atoms;
hydroxyl radicals;
alkoxy radicals containing 1 to 4 carbon atoms;
dialkylamino radicals in which each alkyl portion contains 1 to 4 carbon atoms;
piperidino radicals;
morpholino radicals;
1-piperazinyl radicals optionally substituted at position 4 with an alkyl radical containing 1 to 4 carbon atoms or with a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms;
cycloalkyl radicals containing 3 to 6 carbon atoms;
cycloalkenyl radicals containing 4 to 6 carbon atoms;
phenyl radicals optionally substituted with one or more atoms or radicals selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms;
cyano radicals;
carboxyl radicals; and
alkoxycarbonyl radicals in which the alkyl portion contains 1 to 4 carbon atoms,a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more atoms or radicals selected from halogen atoms;
alkyl radicals containing 1 to 4 carbon atoms; and
alkoxy radicals containing 1 to 4 carbon atoms,a 5-membered aromatic heterocyclic radical, or a saturated heterocyclic radical containing 4 to 6 carbon atoms, optionally substituted with one or more alkyl radicals containing 1 to 4 carbon atoms, R3 represents an unbranched or branched alkyl radical containing 1 to 8 carbon atoms, an unbranched or branched alkenyl radical containing 2 to 8 carbon atoms, an unbranched or branched alkynyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a phenyl or α
- or β
-naphthyl radical optionally substituted with one or more identical or different atoms or radicals selected from halogen atoms, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy, alkylthio, aryloxy, arylthio, hydroxyl, hydroxyalkyl, mercapto, formyl, acyl, acylamino, aroylamino, alkoxycarbonylamino, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, nitro and trifluoromethyl radicals, ora 5-membered aromatic heterocycle containing one or more identical or different hetero atoms selected from nitrogen, oxygen and sulphur atoms and optionally substituted with one or more identical or different substituents selected from halogen atoms, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxycarbonylamino, acyl, arylcarbonyl, cyano, carboxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl and alkoxycarbonyl radicals, with the proviso that, in the substituents of the phenyl, α
- or β
-naphthyl and aromatic heterocyclic radicals in the definitions of R2 and R3, the alkyl radicals and the alkyl portions of the other radicals contain 1 to 4 carbon atoms, and the alkenyl and alkynyl radicals contain 2 to 8 carbon atoms, and the aryl radicals are phenyl or α
- or β
-naphthyl radicals,R4 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain and R5 represents an alkoxy radical containing 1 to 6 carbon atoms in an unbranched or branched chain, said process comprising; treating a product of formula (XVI);
##STR41## in which R1, R3, R6 and R7 are defined as above, with a product of formula (X);
space="preserve" listing-type="equation">(R).sub.3 Si--Hal (X)in which the symbols R, which may be identical or different, represent an alkyl radical containing 1 to 6 carbon atoms, optionally substituted with a phenyl radical, or a cycloalkyl radical containing 3 to 6 carbon atoms or a phenyl radical, to obtain a product of formula (XVII);
##STR42## in which R, R1, R3, R6 and R7 are defined as above, functionalizing said compound of formula (XVII) at position 10 with a product of formula;
space="preserve" listing-type="equation">R'"'"'.sub.4 --X.sub.1 (XII)in which R'"'"'4 represents a radical such that R'"'"'4 --O is identical to R4 defined as above and X1 represents a halogen atom or a reactive ester residue, to give a product of formula (XVIII);
##STR43## in which R, R1, R3, R4, R6 and R7 are defined as above, replacing the silyl protective group of said product of formula (XVIII) by a hydrogen atom to give a product of formula (XIX);
##STR44## in which R1, R3, R4, R6 and R7 are defined as above which, when reacted with a product of formula (XV);
space="preserve" listing-type="equation">R'"'"'.sub.5 --X.sub.2 (XV)in which R'"'"'5 represents a radical such that R'"'"'5 O is identical to R5 defined above and X2 represents a reactive ester residue or a halogen atom, yields the product of formula (V);
##STR45## in which R1, R3, R4, R5, R6 and R7 are defined as aboveand replacing the protective group(s) of formula (V) with one or two hydrogen atoms to give a product of formula (I) in which Z represents a radical of formula (II).
- ##STR39## in which;
Specification
-
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Litigation Data
-
Current AssigneeSanofi Mature IP (Sanofi )
-
Original AssigneeRhone-Poulenc Rorer S.A.
-
InventorsBouchard, Herve, Bourzat, Jean-Dominique, Commer.cedilla.on, Alain
-
Primary Examiner(s)Trinh, Ba K.
-
Application NumberUS08/622,011Time in Patent Office987 DaysField of Search549/510, 549/511US Class Current549/510CPC Class CodesC07D 305/14 condensed with carbocyclic ...
