Antifungal compositions
DC CAFC
First Claim
1. A pharmaceutical composition for intravenous administration to a patient comprisinga) a pharmaceutically effective amount of a compound having the formula ##STR9## and the pharmaceutically acceptable salts thereof, b) a pharmaceutically acceptable amount of an excipient effective to form a lyophilized cake;
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Litigations
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Accused Products
Abstract
The invention is a pharmaceutical composition for intravenous administration to a patient comprising
a) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; and
c) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.
35 Citations
9 Claims
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1. A pharmaceutical composition for intravenous administration to a patient comprising
a) a pharmaceutically effective amount of a compound having the formula ##STR9## and the pharmaceutically acceptable salts thereof, b) a pharmaceutically acceptable amount of an excipient effective to form a lyophilized cake; - and
c) a pharmaceutically acceptable amount of an acetate buffer effective to provide a pharmaceutically acceptable pH. - View Dependent Claims (2, 3, 4, 5, 6, 9)
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7. A process for making a pharmaceutical composition containing a compound having the formula ##STR10## and the pharmaceutically acceptable salts thereof, which comprises the steps of
a) dissolving a bulking agent or combination of agents in water; -
b) adding acetic acid and adjusting the pH to about 3.7; c) adding Compound I and adjusting the pH to about 5 with base; d) filtering the solution thus prepared; e) filling said solution into a lyophilization vial and freezing at -50°
C.; andf) freeze drying the frozen solution. - View Dependent Claims (8)
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Specification
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- Resources
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Current AssigneeMerck Sharp & Dohme Corporation (Merck & Co., Inc.)
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Original AssigneeMerck & Co., Inc.
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InventorsNerurkar, Maneesh J., Kaufman, Michael J., Hunke, William A.
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Primary Examiner(s)Witz, Jean C.
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Assistant Examiner(s)HANLEY, SUSAN MARIE
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Application NumberUS08/827,510Time in Patent Office900 DaysField of Search514/971, 514/970, 514/11, 514/9, 514/2, 424/489, 424/499, 530/317US Class Current514/3.3CPC Class CodesA61K 38/12 Cyclic peptides , e.g. baci...A61K 47/12 Carboxylic acids; Salts or ...A61K 47/26 Carbohydrates, e.g. sugar a...A61K 9/0019 Injectable compositions; In...A61K 9/19 lyophilised , i.e. freeze-d...
