Mometasone furoate monohydrate, process for making same and pharmaceutical compositions
DC CAFC
First Claim
Patent Images
1. 9.alpha.,21-dichloro-16α
- -methyl-1,4-pregnadiene-11β
,17α
-diol-3,20-dione-17-(2'"'"'-furoate) monohydrate.
3 Assignments
Litigations
0 Petitions
Accused Products
Abstract
The invention relates to the novel compound mometasone furoate monohydrate, process for its preparation and pharmaceutical compositions containing said compound.
111 Citations
12 Claims
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1. 9.alpha.,21-dichloro-16α
- -methyl-1,4-pregnadiene-11β
,17α
-diol-3,20-dione-17-(2'"'"'-furoate) monohydrate.
- -methyl-1,4-pregnadiene-11β
- 2. A pharmaceutical composition comprising an antiinflammatory amount of mometasone furoate monohydrate in a pharmaceutically acceptable carrier.
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5. The compound 9α
- ,21-dichloro-16α
-methyl-1,4-pregnadiene-11β
,17α
-diol-3,20 dione-17-(2'"'"'-furoate) monohydrate exhibiting a x-ray crystallographic powder diffraction pattern having essentially the following values;
space="preserve" listing-type="tabular">______________________________________ Angle of Spacing 2θ
d Relative Intensity (degrees) (Å
) |/| ______________________________________ 7.795 11.3324 100 11.595 7.6256 6 12.035 7.3478 3 12.925 6.8437 11 14.070 6.2893 22 14.580 6.0704 5 14.985 5.9072 12 15.225 5.8146 33 15.635 5.6631 96 16.710 5.3011 15 17.515 5.0592 14 18.735 4.7324 12 20.175 4.3978 13 20.355 4.3593 6 20.520 4.3246 4 21.600 3.1108 5 21.985 3.0396 22 22.420 3.9622 8 22.895 3.8811 7 23.245 3.8234 14 23.550 3.7746 13 24.245 3.6680 4 24.795 3.5878 11 24.900 3.5729 5 25.800 3.4503 5 25.985 3.4262 3 26.775 3.3268 84 27.170 3.2794 10 27.305 3.2635 9 27.710 3.2167 5 28.385 3.1417 7 29.165 3.0594 1 29.425 3.0330 2 29.725 3.0030 2 30.095 3.9670 7 30.255 2.9516 3 30.490 2.9294 10 30.725 2.9075 6 31.115 2.8720 3 31.595 2.8294 47 32.135 2.7831 6 32.985 2.7133 7 33.400 2.6805 2 33.820 2.6482 2 34.060 2.6301 8 34.625 2.5885 4 34.795 2.5762 2 35.315 2.5394 1 36.780 2.4416 21 37.295 2.4090 2 ______________________________________
- ,21-dichloro-16α
- 6. A pharmaceutical composition comprising mometasone furoate monohydrate in a carrier consisting essentially of water.
Specification
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Litigation Data
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Current AssigneeMerck Sharp & Dohme Corporation (Merck & Co., Inc.)
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Original AssigneeSchering Corporation (Merck & Co., Inc.)
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InventorsYuen, Pui-Ho, Etlinger, Teresa, Levine, Nancy, Eckhart, Charles
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Primary Examiner(s)Dees, Jose'G.
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Assistant Examiner(s)BADIO, BARBARA P
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Application NumberUS07/984,573Time in Patent Office888 DaysField of Search540/115, 540/114, 514/172, 514/171US Class Current514/172CPC Class CodesA61K 31/58 containing heterocyclic rin...C07J 17/00 Normal steroids containing ...
