Methods for administration of antibiotics
DC CAFC
First Claim
1. A method for administering daptomycin, comprising the step of administering to a human patient in need thereof a therapeutically effective amount of daptomycin in a dose of 3 to 75 mg/kg of daptomycin at a dosage interval that minimizes skeletal muscle toxicity, wherein the daptomycin dose is repeatedly administered at a dosage interval of once every 24 hours to once every 48 hours.
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Litigations
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Accused Products
Abstract
The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin'"'"'s efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that does not result in muscle toxicity.
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Citations
45 Claims
- 1. A method for administering daptomycin, comprising the step of administering to a human patient in need thereof a therapeutically effective amount of daptomycin in a dose of 3 to 75 mg/kg of daptomycin at a dosage interval that minimizes skeletal muscle toxicity, wherein the daptomycin dose is repeatedly administered at a dosage interval of once every 24 hours to once every 48 hours.
- 12. A method for administering daptomycin, comprising the step of administering to a human patient in need thereof a therapeutically effective amount of daptomycin at a dose of 3 to 75 mg/kg of daptomycin at a dosage interval that minimizes skeletal muscle toxicity, wherein the daptomycin dose is repeatedly administered at a dosage interval of once every 24 hours.
- 26. A method for treating or eradicating a bacterial infection in a human patient in need thereof, comprising the step of administering a therapeutically effective amount of daptomycin in a dose of 3 to 75 mg/kg to the patient at a dosage interval that minimizes skeletal muscle toxicity, wherein the daptomycin dose is repeatedly administered at the dosage interval of once every 24 hours to once every 48 hours until said bacterial infection is treated or eradicated.
Specification
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- Resources
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Current AssigneeCubist Pharmaceuticals, LLC (Merck & Co., Inc.)
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Original AssigneeCubist Pharmaceuticals, Inc. (Merck & Co., Inc.)
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InventorsOleson, Frederick B. Jr., Tally, Francis P.
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Primary Examiner(s)Dees, Jose G.
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Assistant Examiner(s)CHOI, FRANK I
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Application NumberUS09/406,568Time in Patent Office1,124 DaysField of Search424/114, 424/116, 514/9, 514/11, 514/183, 530/317US Class Current514/2.9CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 38/08 Peptides having 5 to 11 ami...A61K 38/10 Peptides having 12 to 20 am...A61K 38/12 Cyclic peptides , e.g. baci...A61P 31/00 Antiinfectives, i.e. antibi...A61P 31/04 Antibacterial agents
