Pyrrole substituted 2-indolinone protein kinase inhibitors
DC CAFC
First Claim
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1. A compound that is the L-malate salt of 5-(5-fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide.
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Abstract
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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2 Claims
- 1. A compound that is the L-malate salt of 5-(5-fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide.
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Litigation Data
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Current AssigneeAgouron Pharmaceuticals Incorporated (Pfizer Inc.)
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Original AssigneeAgouron Pharmaceuticals Incorporated (Pfizer Inc.)
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InventorsMiller, Todd A., Liang, Congxin, Li, Xiaoyuan, Tang, Peng Cho, Sun, Li, Vojkovsky, Tomas, Hawley, Michael, Wei, Chung Chen, Nematalla, Asaad S., Shirazian, Shahrzad
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Primary Examiner(s)Stockton, Laura L.
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Application NumberUS11/028,477Publication NumberTime in Patent Office658 DaysField of Search484/68, 514/414US Class Current514/414CPC Class CodesA61P 17/06 AntipsoriaticsA61P 19/02 for joint disorders, e.g. a...A61P 29/00 Non-central analgesic, anti...A61P 3/10 for hyperglycaemia, e.g. an...A61P 35/00 Antineoplastic agentsA61P 37/00 Drugs for immunological or ...A61P 37/06 Immunosuppressants, e.g. dr...A61P 43/00 Drugs for specific purposes...A61P 9/00 Drugs for disorders of the ...C07D 207/33 with substituted hydrocarbo...C07D 209/44 Iso-indoles; Hydrogenated i...C07D 231/12 with only hydrogen atoms, h...C07D 233/56 with only hydrogen atoms or...C07D 249/08 1,2,4-Triazoles; Hydrogenat...C07D 401/12 linked by a chain containin...C07D 401/14 containing three or more he...C07D 403/06 linked by a carbon chain co...C07D 403/12 linked by a chain containin...C07D 403/14 containing three or more he...
