Derivatives of 3,3-diphenylpropylamines
DC CAFC
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Abstract
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
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Citations
8 Claims
- 1. 3,3-Diphenylpropylamines of the general formula
- 4. A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of a 3,3-Diphenylpropylamine of the general formula
Specification
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Litigation Data
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Current AssigneeUCB Pharma GmbH (UCB SA)
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Original AssigneeUCB Pharma GmbH (UCB SA)
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InventorsSparf, Bengt, Meese, Claus
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Primary Examiner(s)JARRELL, NOBLE E
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Application NumberUS12/814,982Publication NumberTime in Patent Office407 DaysField of SearchNoneUS Class Current514/513CPC Class CodesA61P 1/00 Drugs for disorders of the ...A61P 1/04 for ulcers, gastritis or re...A61P 13/00 Drugs for disorders of the ...A61P 13/02 of urine or of the urinary ...A61P 13/10 of the bladderA61P 21/00 Drugs for disorders of the ...A61P 25/02 for peripheral neuropathiesA61P 43/00 Drugs for specific purposes...C07C 217/48 the carbon skeleton being u...C07C 217/62 linked by carbon chains hav...C07C 219/28 having amino groups bound t...C07C 229/34 the carbon skeleton contain...C07C 271/44 to hydrogen atoms or to car...C07C 271/52 to carbon atoms of hydrocar...C07C 307/02 Monoamides of sulfuric acid...
