Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
First Claim
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1. A method for inducing an immune response against hepatitis virus comprising:
- administering to a subject infected with hepatitis virus, a synthetic oligonucleotide having a sequence including at least the following formula;
5′
X1X2CGX3X43′
wherein the oligonucleotide is 8 to 100 nucleotides in length wherein C is unmethylated and wherein X1X2 and X3X4 are nucleotides, wherein the oligonucleotide is SEQ ID NO. 77, in an effective amount to produce an immune response against the hepatitis virus, and further comprising administering an antigen and a non-nucleic acid adjuvant, wherein the oligonucleotide and the non-nucleic acid adjuvant are administered in an amount specific for inducing a synergistic antigen-specific immune response.
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Abstract
The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
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19 Claims
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1. A method for inducing an immune response against hepatitis virus comprising:
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administering to a subject infected with hepatitis virus, a synthetic oligonucleotide having a sequence including at least the following formula;
5′
X1X2CGX3X43′wherein the oligonucleotide is 8 to 100 nucleotides in length wherein C is unmethylated and wherein X1X2 and X3X4 are nucleotides, wherein the oligonucleotide is SEQ ID NO. 77, in an effective amount to produce an immune response against the hepatitis virus, and further comprising administering an antigen and a non-nucleic acid adjuvant, wherein the oligonucleotide and the non-nucleic acid adjuvant are administered in an amount specific for inducing a synergistic antigen-specific immune response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for inducing an immune response comprising:
administering to a subject having cancer, a synthetic oligonucleotide having a sequence of SEQ ID NO. 77, in an effective amount to produce an antigen specific immune response, and further comprising administering an antigen and a non-nucleic acid adjuvant, wherein the oligonucleotide and the non-nucleic acid adjuvant are administered in an amount specific for inducing a synergistic antigen-specific immune response. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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