Soft-gelatin capsule formulation
DC
First Claim
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1. A soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises:
- a soft gelatin capsule shell comprising gelatin and a sugar alcohol as a plasticizer, anda mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle, which is filled in the shell,wherein the pharmaceutically acceptable vehicle is a fatty acid ester or a polyol,wherein the 15-keto-prostaglandin compound is a compound of the formula (I);
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Abstract
The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
27 Citations
23 Claims
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1. A soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises:
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a soft gelatin capsule shell comprising gelatin and a sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle, which is filled in the shell, wherein the pharmaceutically acceptable vehicle is a fatty acid ester or a polyol, wherein the 15-keto-prostaglandin compound is a compound of the formula (I); - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 23)
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21. A soft gelatin capsule formulation comprising:
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a soft gelatin capsule shell comprising gelatin and a sugar alcohol as a plasticizer, and a mixture comprising
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22. A soft gelatin capsule formulation comprising:
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a soft gelatin capsule shell comprising gelatin and a sugar alcohol as a plasticizer, and a mixture comprising
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Specification
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Litigation Data
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Current AssigneeSucampo GmbH (Mallinckrodt plc)
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Original AssigneeR-Tech UENO Limited (Mallinckrodt plc), Sucampo AG (Mallinckrodt plc)
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InventorsHashitera, Yukiko, Hirata, Ryu, Harada, Yasuhiro, Ueno, Ryuji
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Primary Examiner(s)VALENROD, YEVGENY
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Application NumberUS13/210,556Publication NumberTime in Patent Office497 DaysField of SearchNoneUS Class Current562/504CPC Class CodesA61K 31/352 condensed with carbocyclic ...A61K 31/557 Eicosanoids, e.g. leukotrie...A61K 31/5575 having a cyclopentane, e.g....A61K 9/4816 Wall or shell materialA61K 9/4825 Proteins, e.g. gelatin gela...A61K 9/4858 Organic compoundsA61P 1/00 Drugs for disorders of the ...A61P 1/10 LaxativesA61P 43/00 Drugs for specific purposes...
