Spreading implement
DC CAFC
First Claim
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1. A method of increasing the testosterone blood level of a person in need thereof comprising applying to at least one axilla of the person a liquid pharmaceutical composition comprising testosterone and a carrier wherein said composition is applied with an implement comprising:
- a support; and
a receptacle mounted on the support and defining a reservoir space with an open top and being configured to receive the liquid in the reservoir space through the open top, wherein the receptacle includes a flexible membrane integrally forming a base and a wall, the wall being substantially transverse to the base and having a working surface configured to spread the liquid over the treatment surface, wherein the base has a continuous surface such that liquid cannot pass through the base, wherein the wall includes an inner portion which extends from the base to an upper end and an outer skirt portion, wherein the inner portion and skirt portion form a double-wall structure, and wherein at least the wall is resiliently deformable so in use the working surface maintains contact with the treatment surface when spreading the liquid.
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Abstract
Described are methods comprising applying a liquid pharmaceutical testosterone composition with an implement comprising a support and a receptacle mounted on the support and defining a reservoir space with an open top to receive the liquid, wherein the receptacle includes a flexible membrane integrally forming a base and a wall, the wall being substantially transverse to the base and having a working surface to spread the liquid over the treatment surface, wherein the base has a continuous surface such that liquid cannot pass through the base, wherein the wall includes an inner portion which extends from the base to an upper end and an outer skirt portion, wherein the inner portion and skirt portion form a double-wall structure, and wherein at least the wall is resiliently deformable so the working surface maintains contact with the treatment surface when spreading the liquid.
36 Citations
23 Claims
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1. A method of increasing the testosterone blood level of a person in need thereof comprising applying to at least one axilla of the person a liquid pharmaceutical composition comprising testosterone and a carrier wherein said composition is applied with an implement comprising:
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a support; and a receptacle mounted on the support and defining a reservoir space with an open top and being configured to receive the liquid in the reservoir space through the open top, wherein the receptacle includes a flexible membrane integrally forming a base and a wall, the wall being substantially transverse to the base and having a working surface configured to spread the liquid over the treatment surface, wherein the base has a continuous surface such that liquid cannot pass through the base, wherein the wall includes an inner portion which extends from the base to an upper end and an outer skirt portion, wherein the inner portion and skirt portion form a double-wall structure, and wherein at least the wall is resiliently deformable so in use the working surface maintains contact with the treatment surface when spreading the liquid. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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3. A method according to clam 2, wherein the one or more penetration enhancers is selected from the group consisting of fatty acids, fatty acid esters, fatty alcohols, glycols and glycol esters, 1,3-dioxolanes and 1,3-dioxanes, macrocyclic ketones containing at least 12 carbon atoms, oxazolidinones and oxazolidinone derivatives, alkyl-2-(N,N-disubstituted amino)-alkanoate esters, (N,N-disubstituted amino)-alkanol alkanoates, sunscreen esters and mixtures thereof.
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13. A method of increasing the testosterone blood level of a person in need thereof comprising applying to at least one axilla of the person a liquid pharmaceutical composition comprising testosterone and a carrier wherein said composition is applied with an implement comprising:
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a support; and a receptacle mounted on the support and defining a reservoir space with an open top and being configures to receive liquid in the reservoir space through the open top, wherein the receptacle includes a flexible membrane integrally forming a base and a wall, the wall being substantially transverse to the base and having a working surface configured to spread the liquid over the treatment surface, wherein the base has a continuous surface such that liquid cannot pass through the base, wherein the wall includes an inner portion which extends from the base to an upper end and an outer skirt portion;
wherein the inner portion and skirt portion form a double walled structure, andwherein at least the wall is resiliently deformable so in use the working surface maintains contact with the treatment surface when spreading the liquid; and wherein the liquid pharmaceutical composition comprises; (i) a pharmaceutically effective amount of testosterone; (ii) octyl salicylate penetration enhancer in an amount of from 0.01% to 15% w/v of the liquid; (iii) volatile solvent selected from the group consisting of ethanol, isopropanol and mixtures thereof in a total amount of from 70% to 99% v/v of the liquid; and (iv) a viscosity modulating agent in an amount to provide the liquid with a viscosity greater than water and less than 300 centipoise. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification
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Litigation Data
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Current AssigneeAcrux DDS Pty Ltd (Acrux Limited)
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Original AssigneeAcrux DDS Pty Ltd (Acrux Limited)
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InventorsBayly, Peter, Bayly, Mark Simon, Ahlstrom, Magnus, Watkinson, Adam Charles
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Primary Examiner(s)WALCZAK, DAVID J
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Application NumberUS13/464,556Publication NumberTime in Patent Office347 DaysField of Search401/9, 401/11, 401/261, 401/264, 401/265, 401/266, 424/443US Class Current401/265CPC Class CodesA45D 34/04 Appliances specially adapte...A45D 40/26 Appliances specially adapte...A61K 2800/48 Thickener, Thickening systemA61K 2800/592 Mixtures of compounds compl...A61K 31/565 not substituted in position...A61K 31/568 substituted in positions 10...A61K 31/57 substituted in position 17 ...A61K 47/14 Esters of carboxylic acids,...A61K 8/26 Aluminium; Compounds thereofA61K 9/0014 Skin, i.e. galenical aspect...A61M 35/003 Portable hand-held applicat...A61Q 15/00 Anti-perspirants or body de...
