Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
DC CAFC
First Claim
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1. An isolated monoclonal antibody, wherein, when bound to PCSK9, said monoclonal antibody binds to at least one residue within the sequence set forth by residues 123-132 of SEQ ID NO:
- 1, and wherein said monoclonal antibody reduces binding between PCSK9 and an EGFa domain of LDLR protein antagonizes PCSK9'"'"'s inhibition of cellular LDL uptake.
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Abstract
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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6 Claims
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1. An isolated monoclonal antibody, wherein, when bound to PCSK9, said monoclonal antibody binds to at least one residue within the sequence set forth by residues 123-132 of SEQ ID NO:
- 1, and wherein said monoclonal antibody reduces binding between PCSK9 and an EGFa domain of LDLR protein antagonizes PCSK9'"'"'s inhibition of cellular LDL uptake.
- View Dependent Claims (2, 3, 4, 5, 6)
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Litigation Data
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Current AssigneeAmgen Inc.
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Original AssigneeAmgen Inc.
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InventorsJackson, Simon Mark, Walker, Nigel Pelham Clinton, Piper, Derek Evan, Shen, Wenyan, King, Chadwick Terence, Ketchem, Randal Robert, Mehlin, Christopher, Carabeo, Teresa Arazas
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Primary Examiner(s)WEN, SHARON X
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Application NumberUS12/474,176Publication NumberTime in Patent Office1,608 DaysField of SearchNoneUS Class Current530/388.26CPC Class CodesA61K 2039/505 comprising antibodiesA61K 2300/00 Mixtures or combinations of...A61K 31/22 of acyclic acids, e.g. prav...A61K 31/366 having six-membered rings, ...A61K 31/40 having five-membered rings ...A61K 31/405 Indole-alkanecarboxylic aci...A61K 31/44 Non condensed pyridines; Hy...A61K 31/47 Quinolines; IsoquinolinesA61K 31/505 Pyrimidines; Hydrogenated p...A61K 31/66 Phosphorus compoundsA61K 39/395 Antibodies agglutinins A61K...A61K 39/3955 against proteinaceous mater...A61K 45/06 Mixtures of active ingredie...A61P 25/28 for treating neurodegenerat...A61P 3/00 Drugs for disorders of the ...A61P 3/06 AntihyperlipidemicsA61P 43/00 Drugs for specific purposes...A61P 7/00 Drugs for disorders of the ...A61P 9/00 Drugs for disorders of the ...A61P 9/10 for treating ischaemic or a...View All
