Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-O-(2-hydroxyethyl)-rapamycin
First Claim
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1. The use of 40-O-(2-hydroxyethyl)-rapamycin in the manufacture of a medicament for co-administration in synergistically effective amounts with cyclosporin A.
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Abstract
A synergistic combination of an IL-2 transcription inhibitor (e.g., cyclosporin A or FK506) and 40-O-(2-hydroxyethyl)-rapamycin is provided, which is useful in the treatment and prevention of transplant rejection and also certain autoimmune and inflammatory diseases, together with novel pharmaceutical compositions comprising an IL-2 transcription inhibitor in combination with a rapamycin, e.g., 40-O-(2-hydroxyethyl)-rapamycin.
4 Citations
12 Claims
- 1. The use of 40-O-(2-hydroxyethyl)-rapamycin in the manufacture of a medicament for co-administration in synergistically effective amounts with cyclosporin A.
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5. A kit of parts comprising cyclosporin A and 40-O-(2-hydroxyethyl)-rapamycin in separate unit dosage forms, wherein said unit dosage forms are suitable for administration of the two compounds in synergistically effective amounts, together with instructions for use.
- 6. Cyclosporin A and 40-O-(2-hydroxyethyl)-rapamycin as a combined pharmaceutical preparation for simultaneous, separate or sequential use in synergistically effective amounts.
- 8. A pharmaceutical composition comprising cyclosporin A and 40-O-(2-hydroxyethyl)-rapamycin in a synergistically effective ratio in combination or association with a pharmaceutically acceptable diluent or carrier.
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Current AssigneeArmin Meinzer, Barbara Haeberlin, Gerhard Zenke, Hendrik Schuurman
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Original AssigneeArmin Meinzer, Barbara Haeberlin, Gerhard Zenke, Hendrik Schuurman
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InventorsZenke, Gerhard, Meinzer, Armin, Haeberlin, Barbara, Schuurman, Hendrik
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current514/183
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CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/445 Non condensed piperidines, ...A61K 31/45 having oxo groups directly ...A61K 31/70 Carbohydrates; Sugars; Deri...A61K 38/13 CyclosporinsA61K 45/06 Mixtures of active ingredie...A61K 9/146 with organic macromolecular...A61K 9/4858 Organic compoundsA61P 17/14 for baldness or alopeciaA61P 29/00 Non-central analgesic, anti...A61P 37/00 Drugs for immunological or ...A61P 37/02 ImmunomodulatorsA61P 37/06 Immunosuppressants, e.g. dr...A61P 37/08 Antiallergic agents antiast...A61P 43/00 Drugs for specific purposes...
