Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-O-(2-hydroxyethyl)-rapamycin
DC CAFCFirst Claim
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1. An IL-2 transcription inhibitor and 40-O-(2-hydroxyethyl)-rapamycin as a combined pharamceutical preparation in the weight ratio 2:
- 1 to 180;
1 for simultaneous, separate, or sequential use in synergistically effective amounts.
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Abstract
A synergistic combination of an IL-2 transcription inhibitor (e.g., cyclosporin A or FK506) and 40-O-(2-hydroxyethyl)-rapamycin is provided, which is useful in the treatment and prevention of transplant rejection and also certain autoimmune and inflammatory diseases, together with novel pharmaceutical compositions comprising an IL-2 transcription inhibitor in combination with a rapamycin, e.g., 40-O-(2-hydroxyethyl)-rapamycin.
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20 Claims
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1. An IL-2 transcription inhibitor and 40-O-(2-hydroxyethyl)-rapamycin as a combined pharamceutical preparation in the weight ratio 2:
- 1 to 180;
1 for simultaneous, separate, or sequential use in synergistically effective amounts.
- 1 to 180;
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2. A pharmaceutical composition comprising (I) an IL-2 transcription inhibitor and (II) 40-O-(2-hydroxyethyl)-rapamycin, wherein the weight ratio II is 2:
- 1 to 180;
1, in combination or association with a pharmaceutically acceptable diluent or carrier. - View Dependent Claims (3, 4, 5, 6)
- 1 to 180;
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7. A method of treating or preventing an autoimmune or inflammatory condition or transplant rejection in a subject suffering from or at risk for such condition or rejection, comprising co-administering synergistically effective amounts of (I) an IL-2 transcription inhibitor and (II) 40-O-(2-hydroxyethyl)-rapamycin in the weight ratio 2:
- 1 to 180;
1. - View Dependent Claims (8, 9, 10)
- 1 to 180;
- 11. A method of treating or preventing chronic rejection of a heart, lung, or kidney transplant in a subject suffering from or at risk for such rejection, comprising co-administering together or at substantially the same time synergistically effective amounts of (I) an IL-2 transcription inhibitor and (II) 40-O-(2-hydroxyethyl)-rapamycin.
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18. A kit comprising (I) an IL-2 transcription inhibitor and (II) 40-O-(2-hydroxyethyl)-rapamycin in separate unit dosage forms, wherein said unit dosage forms are suitable for administrating I and II in synergistically effective amounts, wherein the weight ratio II is 2:
- 1 to 180;
1. - View Dependent Claims (19, 20)
- 1 to 180;
Specification