Method of Making Particles For Use In A Pharmaceutical Composition
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Abstract
The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
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Citations
40 Claims
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1-34. -34. (canceled)
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35. Composite active particles for use in a pharmaceutical composition for pulmonary administration, each composite active particle comprising a particle of active material and additive material on the surface of that particle of active material, wherein the composite active particles have a mass median aerodynamic diameter of not more than 10 μ
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- View Dependent Claims (36, 37, 38, 39, 40)
Specification
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Current AssigneeVectura Limited (Vectura Group Ltd.)
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Original AssigneeVectura Limited (Vectura Group Ltd.)
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InventorsMORTON, David Alexander Vodden, GREEN, Matthew Michael James, STANIFORTH, John Nicholas
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current424/45
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CPC Class CodesA61K 31/137 Arylalkylamines, e.g. amphe...A61K 47/06 Organic compounds, e.g. nat...A61K 47/10 Alcohols; Phenols; Salts th...A61K 47/12 Carboxylic acids; Salts or ...A61K 47/32 Macromolecular compounds ob...A61K 47/44 Oils, fats or waxes accordi...A61K 9/0075 for inhalation via a dry po...A61K 9/008 comprising drug dissolved o...A61K 9/145 with organic compoundsA61K 9/1617 Organic compounds, e.g. pho...A61K 9/167 with an outer layer or coat...A61K 9/50 Microcapsules having a gas,...A61K 9/501 Inorganic compoundsA61K 9/5015 Organic compounds, e.g. fat...A61K 9/5089 ProcessesA61K 9/5115 Inorganic compoundsA61P 11/06 Antiasthmatics
