Method of making particles for use in a pharmaceutical composition
DC CAFCFirst Claim
1. Composite active particles for use in a pharmaceutical composition for pulmonary administration, each composite active particle comprising a particle of active material and particulate additive material on the surface of that particle of active material, wherein the composite active particles have a mass median aerodynamic diameter of not more than 10 μ
- m, and wherein the additive material promotes the dispersion of the composite active particles upon actuation of a delivery device.
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Abstract
The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
71 Citations
10 Claims
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1. Composite active particles for use in a pharmaceutical composition for pulmonary administration, each composite active particle comprising a particle of active material and particulate additive material on the surface of that particle of active material, wherein the composite active particles have a mass median aerodynamic diameter of not more than 10 μ
- m, and wherein the additive material promotes the dispersion of the composite active particles upon actuation of a delivery device.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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