PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ACUTE DISORDERS
1 Assignment
0 Petitions
Accused Products
Abstract
A pharmaceutical composition for the treatment of acute disorders is described. The composition comprises an essentially water-free, ordered mixture of at least one pharmaceutically active agent in the form of microparticles which are adhered to the surfaces of carrier particles which are substantially larger than the particles of the active agent or agents, and are essentially water-soluble, in combination with the bioadhesion and/or mucoadhesion promoting agent. The invention also relates to a method for preparing the composition and to the use of the composition for the treatment of acute disorders.
2 Citations
31 Claims
-
1-17. -17. (canceled)
-
18. A bioadhesive and/or mucoadhesive pharmaceutical composition for the treatment of acute disorders by sublingual administration in the form of a tablet sized for placement under a tongue comprising:
-
(a) water-soluble carrier particles having exterior surfaces, (b) microparticles of at least one pharmaceutically active agent, wherein the microparticles are smaller than the carrier particles and are admixed with the carrier particles, and (c) particles of a bioadhesion and/or mucoadhesion promoting agent consisting essentially of a polymer that swells when brought into contact with saliva, admixed with the carrier particles, wherein both the microparticles of the at least one pharmaceutically active agent and the particles of the bioadhesion and/or mucoadhesion promoting agent adhere as particles to the exterior surfaces of the carrier particles. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
-
-
31. A method of treating an acute disorder comprising
providing a pharmaceutical composition in the form of a tablet sized for placement under a tongue, wherein the composition comprises (a) water-soluble carrier particles having exterior surfaces, (b) microparticles of at least one pharmaceutically active agent, wherein the microparticles are smaller than the carrier particles and are admixed with the carrier particles, and (c) particles of a bioadhesion and/or mucoadhesion promoting agent consisting essentially of a polymer that swells when brought into contact with saliva, admixed with the carrier particles, wherein both the microparticles of the at least one pharmaceutically active agent and the particles of the bioadhesion and/or mucoadhesion promoting agent adhere as particles to the exterior surfaces of the carrier particles, and sublingually administering the pharmaceutical composition to the individual.
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeOrexo AB
-
Original AssigneeOrexo AB
-
InventorsPETTERSSON, ANDERS, NYSTROM, CHRISTER
-
Granted Patent
-
Time in Patent OfficeDays
-
Field of Search
-
US Class Current424/464
-
CPC Class CodesA61K 31/136 having the amino group dire...A61K 31/19 Carboxylic acids, e.g. valp...A61K 31/196 the amino group being direc...A61K 31/34 having five-membered rings ...A61K 31/341 not condensed with another ...A61K 31/44 Non condensed pyridines; Hy...A61K 31/4439 containing a five-membered ...A61K 31/445 Non condensed piperidines, ...A61K 31/4468 having a nitrogen directly ...A61K 31/4745 condensed with ring systems...A61K 31/485 Morphinan derivatives, e.g....A61K 31/4985 Pyrazines or piperazines or...A61K 31/5415 ortho- or peri-condensed wi...A61K 31/5513 1,4-Benzodiazepines, e.g. d...A61K 31/635 having a heterocyclic ring,...A61K 36/84 Valerianaceae (Valerian fam...A61K 38/00 Medicinal preparations cont...A61K 38/2242 Atrial natriuretic factor c...A61K 9/0056 Mouth soluble or dispersibl...A61K 9/006 Oral mucosa, e.g. mucoadhes...View All
