Pharmaceutical composition for the treatment of acute disorders
DC CAFC
First Claim
1. A method comprising sublingual administration to an individual of a pharmaceutical composition in the form of a tablet sized for placement under a tongue, wherein the composition comprises(a) water-soluble carrier particles having exterior surfaces,(b) microparticles of buprenorphine or a pharmaceutically-acceptable salt thereof, wherein said microparticles are smaller than the carrier particles and are admixed with the carrier particles, and(c) particles of a bioadhesion and/or mucoadhesion promoting agent consisting essentially of a polymer that swells when brought into contact with saliva, admixed with the carrier particles,wherein the microparticles of buprenorphine or a pharmaceutically-acceptable salt thereof are presented at the exterior surfaces of the carrier particles.
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Abstract
A pharmaceutical composition for the treatment of acute disorders is described. The composition comprises an essentially water-free, ordered mixture of at least one pharmaceutically active agent in the form of microparticles which are adhered to the surfaces of carrier particles which are substantially larger than the particles of the active agent or agents, and are essentially water-soluble, in combination with the bioadhesion and/or mucoadhesion promoting agent. The invention also relates to a method for preparing the composition and to the use of the composition for the treatment of acute disorders.
42 Citations
2 Claims
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1. A method comprising sublingual administration to an individual of a pharmaceutical composition in the form of a tablet sized for placement under a tongue, wherein the composition comprises
(a) water-soluble carrier particles having exterior surfaces, (b) microparticles of buprenorphine or a pharmaceutically-acceptable salt thereof, wherein said microparticles are smaller than the carrier particles and are admixed with the carrier particles, and (c) particles of a bioadhesion and/or mucoadhesion promoting agent consisting essentially of a polymer that swells when brought into contact with saliva, admixed with the carrier particles, wherein the microparticles of buprenorphine or a pharmaceutically-acceptable salt thereof are presented at the exterior surfaces of the carrier particles.
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2. A method comprising sublingual administration of at least one dosage unit of an essentially water free pharmaceutical composition to an individual, said pharmaceutical composition comprising an effective amount of buprenorphine or a pharmaceutically-acceptable salt thereof in the form of microparticles adhered to the surfaces of carrier particles which are substantially larger than said microparticles and are essentially water-soluble, and a bioadhesion and/or mucoadhesion promoting agent.
Specification
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- Resources
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Current AssigneeOrexo AB
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Original AssigneeOrexo AB
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InventorsPettersson, Anders, Nystrom, Christer
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Primary Examiner(s)Hartley, Michael G
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Assistant Examiner(s)YOUNG, MICAH PAUL
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Application NumberUS13/302,694Publication NumberTime in Patent Office560 DaysField of Search424465-489US Class Current424/465CPC Class CodesA61K 31/136 having the amino group dire...A61K 31/19 Carboxylic acids, e.g. valp...A61K 31/196 the amino group being direc...A61K 31/34 having five-membered rings ...A61K 31/341 not condensed with another ...A61K 31/44 Non condensed pyridines; Hy...A61K 31/4439 containing a five-membered ...A61K 31/445 Non condensed piperidines, ...A61K 31/4468 having a nitrogen directly ...A61K 31/4745 condensed with ring systems...A61K 31/485 Morphinan derivatives, e.g....A61K 31/4985 Pyrazines or piperazines or...A61K 31/5415 ortho- or peri-condensed wi...A61K 31/5513 1,4-Benzodiazepines, e.g. d...A61K 31/635 having a heterocyclic ring,...A61K 36/84 Valerianaceae (Valerian fam...A61K 38/00 Medicinal preparations cont...A61K 38/2242 Atrial natriuretic factor c...A61K 9/0056 Mouth soluble or dispersibl...A61K 9/006 Oral mucosa, e.g. mucoadhes...View All
